Marble Burying Anxiety

However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents.

Marble burying anxiety.

The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. Mice which are placed individually in a cage bury glass marbles that are present in the cage. However modulation of marble burying by serotonin reuptake inhibitors prompted its link to obsessive compulsive disorder compulsive like behavior. It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when.

It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. The marble burying behavior test is an acute test. This test has some predictive value for anti depressant and or anxiolytic drugs. While widely used there is significant controversy over the interpretation of its results.

The marble burying test is used to record the number of marbles buried by mice placed in a novel environment. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. Marble burying as an anxiety model in conclusion although marble burying was reduced by doses of diazepam and zimeldine which did not affect activity in a locomotor test we have not been able to find other evidence that marble burying models anxiety either from its behavioral characteristics or from the actions of anxiogenic agents.